Due to the popularity of smart mobile terminals, sensitive information such as personal location privacy, check-in data privacy and trajectory privacy in the collected spatio-temporal data are easy to be leaked. In the current researches, protection technologies are proposed for the above privacy leakages respectively, and there is not a personalized spatio-temporal data privacy protection method to prevent the above privacy leakages for users. Therefore, a personalized privacy protection model for spatio-temporal data named ( p, q, ε)-anonymity and a Personalized Privacy Protection for Spatio-Temporal Data (PPP _ST) algorithm based on this model were proposed to protect the users' privacy data with personalized settings (location privacy, check-in data privacy and trajectory privacy). The heuristic rules were designed to generalize the spatio-temporal data to ensure the availability of the published data and realize the high availability of spatio-temporal data. In the comparison experiments, the data availability rate of PPP _ST algorithm is about 4.66% and 15.45% higher than those of Information Data Used through K-anonymity (IDU-K) and Personalized Clique Cloak (PCC) algorithms on average respectively. At the same time, the generalized location search technology was designed to improve the execution efficiency of the algorithm. Experiments and analysis were conducted based on real spatio-temporal data. Experimental results show that PPP _ST algorithm can effectively protect the privacy of personalized spatio-temporal data.